The BRAF mutation is found in several cancers, including thyroid cancer, malignant melanoma, ovarian cancer and colorectal cancer. In the case of thyroid cancer, there are more than 40 different types of BRAF mutation. Of these mutations, the V600E mutation in exon 15, i.e. the nucleotide change from T to A at base 1799 resulting in the amino acid change from valine to glutamate, is the most important with more than 90% frequency. In particular, the BRAF V600E mutation is detected with approx. 45% frequency in papillary thyroid carcinoma and is considered a prognostic factor for thyroid cancer.