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PNAClamp™ Mutation Detection Kit IDH2

For the detection of IDH2 mutations in tissue biopsies

Cat. No. PNAC-5101

PNAClamp™ Mutation Detection Kit IDH2

SKU Pcto-0170 Categories Applications, Glioblastoma and myeloproliferative neoplasm., Oncology, Precision medicine

Description
Additional information

IDH2 is frequently mutated in glioma, acute myeloid leukemia and myelodysplastic syndromes. Mutations generally involve point mutations at residues R140 and R172 of the protein. Mutations in IDH1 and IDH2 result in a detrimental “gain of function”: instead of converting isocitrate to α-ketoglutarate, mutated IDH1 or IDH2 converts isocitrate to 2-hydroxyglutarate. 2-hydroxyglutarate inhibits other proteins involved in epigenetic regulation.

Technical Data	Yes
Marca	Panagene

Equipment

DNA-RNA extraction

Electrophoresis

Plastic Materials

Amplification

Veterinary Diagnostics

PNAClamp™ Mutation Detection Kit IDH2

PNAClamp™ Mutation Detection Kit IDH2

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